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Ancestral Reconstruction of clonally related Immunoglobulin sequences

Science Immunogenetic studies offer fundamental insight into the maturation of immune responses. For instance, the analysis of somatic hypermutation (SHM) within the clonotypic immunoglobulin (IG) helps us to better understand the operation of selective forces in the natural history of any particular B cell clone, while also revealing whether antigen interactions are ongoing. From a…

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